Haeusler lab
 

The Haeusler Lab

Investigating
Metabolic Diseases

Est. 2014

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Insulin signaling

 

Metabolism

 

Metabolic disease

 

Throughout the day, during and between meals, the body must continuously determine:

(1) how much glucose, fat, and cholesterol should be generated or eliminated, and (2) how to transport those molecules between tissues and fluids. Our lab investigates how insulin signaling controls these processes, and how they become disrupted in conditions like insulin resistance, diabetes, liver disease, and atherosclerosis.

#metabolism #cholesterol #bile-acids #lipids #glucose #insulin #diabetes #obesity #atherosclerosis #liver #gut 

Publications

 
 
 
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A full list of publications can be found at: NCBI, Google Scholar, or ORCID

 
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2021-2023

The python-derived 16α-hydroxylated bile acid, pythocholic acid decreases food intake and increases oleoylethanolamide in male mice
Higuchi S Wood C, Nasiri RH, Giddla LJ, Molina V, Diarra R, DiPatrizio NV, Kawamura A, Haeusler RA. (2023)
Endocrinology

An Updated Perspective on the Dual-Track Model of Enterocyte Fat Metabolism
Cook JR, Kohan AB, Haeusler RA. (2022)
J Lipid Res 63: 100278

Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway
Izquierdo MC, Shanmugarajah N, Lee SX, Kraakman MJ, Westerterp M, Kitamoto T, Harris M, Cook JR, Gusarova GA, Zhong K, Marbuary E, O-Sullivan I, Rasmus NF, Camastra S, Unterman T, Ferrannini E, Hurwitz BE, Haeusler RA (2022)
J Clin Invest 132: e146219

Differential effects of bariatric surgery on plasma levels of ANGPTL3 and ANGPTL4
Bini S, D’Erasmo L, Astiarraga B, Minicocci I, Palumbo M, Pecce V, Polito L, Di Costanzo A, Haeusler RA, Arca M, Ferrannini E, Camastra S. (2022)
Nutr Metab Cardiovasc Dis 32: 2647

Sex-specific differences in metabolic outcomes after sleeve gastrectomy and intermittent fasting in obese middle-aged mice
Emiliano AB, Lopatinsky NR, Kraljevic M, Higuchi S, He Y, Haeusler RA, and Schwartz GJ (2022)
Am J Physiol Endocrinol Metab 323: E107

FOXO1 is present in stomach epithelium and determines gastric cell distribution
McKimpson WM, Kuo T, Kitamoto T, Higuchi S, Mills JC, Haeusler RA, Accili D. (2022)
Gastro Hep Advances 1: 733

Hepatocentric leptin signaling modulates gluconeogenesis via MKP-3
Gamarra JR and Haeusler RA (2022)
Cell Mol Gastroenterol Hepatol

Cyp2c-deficiency depletes muricholic acids and protects against high fat diet-induced obesity in male mice but promotes liver damage
Oteng A-B, Higuchi S, Banks AS, Haeusler RA (2021)
Mol Metab 53: 101326

 
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