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Research


The Haeusler lab

Investigating metabolic diseases

est. 2014

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Research


The Haeusler lab

Investigating metabolic diseases

est. 2014

Go to publications →

 

Diabetes

 

Obesity

 

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Atherosclerosis

 

The goals of our research are to understand the development of proatherogenic metabolic abnormalities in insulin resistant individuals, and to identify new therapeutic targets for improving these abnormalities. Two current areas of focus are dysregulation of (i) lipoprotein and (ii) bile acid metabolism. Lipoproteins carry out atherogenic and atheroprotective actions, and may link insulin resistance with cardiovascular disease. Bile acids are involved in maintaining cholesterol, glucose, and triglyceride homeostasis, and are dysregulated during insulin resistance and diabetes. Through these two research areas, we aim to determine mechanisms of metabolic abnormalities and atherogenesis in the natural history of type 2 diabetes, and to identify potential therapeutic targets. 

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Publications


 

Publications

 

 

Publications


 

Publications

 

 

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2018

FoxO Transcription Factors are Required for Hepatic HDL-Cholesterol Clearance
Lee SX, Heine M, Schlein C, Ramakrishnan R, Liu J, Belnavis G, Haimi I, Fischer AW, Ginsberg HN, Heeren J, Rinninger F, and Haeusler RA.
The Journal of  Clinical Investigation 128: 1615-1626

Gamma-secretase inhibition lowers plasma triglyceride-rich lipoproteins by stabilizing the LDL receptor
Kim KJ, Goldberg IJ, Graham MJ, Sundaram M, Bertaggia E, Lee SX, Qiang L, Haeusler RA, Metzger D, Chambon P, Yao Z, Ginsberg HN, and Pajvani UB.
Cell Metabolism 27: 816-827

Metformin and AMP Kinase activation increase expression of the sterol transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) with potential antiatherogenic consequences
Molusky MM, Hsieh J, Lee SX, Ramakrishnan R, Tascau L, Haeusler RA, Accili D, Tall AR.
Arteriosclerosis, Thrombosis, and Vascular Biology 38: 1493-1503

Unexplained reciprocal regulation of diabetes and lipoproteins
Higuchi S, Izquierdo MC, Haeusler RA
Current Opinion in Lipidology 29: 186-193

Biochemical and cellular properties of insulin receptor signaling
Haeusler RA, McGraw TE, Accili D.
Nature Reviews Molecular Cell Biology 19: 31-44

 

2017

Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling
Langlet, Haeusler RA, Linden D, Ericson E, Norris T, Johansson A, Cook JR, Aizawa K, Sang L, Buettner C, Accili D. 
Cell 171: 824-835

Cyp8b1 ablation prevents western diet-induced weight gain and hepatic steatosis because of impaired fat absorption
Bertaggia E, Jensen KK, Castro-Perez J, Xu Y, Di Paolo G, Chan RB, Wang L, Haeusler RA. 
American Journal of Physiology – Endocrinology & Metabolism 313: E121-E133

Group photo


Group photo


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