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Research


The Haeusler lab

Investigating metabolic diseases

est. 2014

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Research


The Haeusler lab

Investigating metabolic diseases

est. 2014

Go to publications →

 

Diabetes

 

Obesity

 

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Atherosclerosis

 

The goals of our research are to understand the development of proatherogenic metabolic abnormalities in insulin resistant individuals, and to identify new therapeutic targets for improving these abnormalities. Two current areas of focus are dysregulation of (i) lipoprotein and (ii) bile acid metabolism. Lipoproteins carry out atherogenic and atheroprotective actions, and may link insulin resistance with cardiovascular disease. Bile acids are involved in maintaining cholesterol, glucose, and triglyceride homeostasis, and are dysregulated during insulin resistance and diabetes. Through these two research areas, we aim to determine mechanisms of metabolic abnormalities and atherogenesis in the natural history of type 2 diabetes, and to identify potential therapeutic targets. 

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Publications


 

Publications

 

 

Publications


 

Publications

 

 

 
 
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2017

Biochemical and cellular properties of insulin receptor signaling
Haeusler RA, McGraw TE, Accili D.
Nature Reviews Molecular Cell Biology in press

Cyp8b1 ablation prevents western diet-induced weight gain and hepatic steatosis due to impaired fat absorption
Bertaggia E, Jensen KK, Castro-Perez J, Xu Y, Di Paolo G, Chan RB, Wang L, Haeusler RA. 
American Journal of Physiology – Endocrinology & Metabolism 313: E121-E133

 

2016

Increased Bile Acid Synthesis and Impaired Bile Acid Transport in Human Obesity
Haeusler RA, Camastra S, Nannipieri M, Astiarraga G, Castro-Perez J, Xie D, Wang L, Chakravarthy M, Ferrannini E. 
Journal of Clinical Endocrinology & Metabolism 101: 1935-1944

 

2015

Increased Bile Acid Synthesis and Deconjugation after Biliopancreatic Diversion
Ferrannini E, Camastra S, Astiarraga G, Nannipieri M, Castro-Perez J, Xie D, Wang L, Chakravarthy M, Haeusler RA.
Diabetes 64: 3377-3385

Temporal changes in bile acid levels and 12-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes
Dutia R, Embrey M, O’Brien C, Haeusler RA, Agenor K, Homel P, McGinty J, Vincent R, Alaghband-Zadeh J, Staels B, Le Roux C, Yu J, and Laferrere B.
International Journal of Obesity 39: 806-813

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2014

Decreased Expression of Hepatic Glucokinase in Type 2 Diabetes
Haeusler RA, Camastra S, Astiarraga B, Nannipieri M, Anselmino N, and Ferranini E.
Molecular Metabolism 4: 222-226

Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors
Haeusler RA, Hartil K, Vaitheesvaran B, Arrieta-Cruz I, Knight CM, Cook JR, Kammoun HL, Febbraio MA, Gutierrez-Juarez R, Kurland IJ, and Accili D.
Nature Communications 5: 5190

 

2013

Human Insulin Resistance is Associated with Increased Plasma Levels of 12-Hydroxylated Bile Acids
Haeusler RA, Astiarraga B, Camastra S, Accili D, and Ferrannini E. 
Diabetes 62: 4184-91

Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencing
Pratt-Hyatt M, Pai DA, Haeusler RA, Wozniak GG, Good PD, Miller EL, McLeod IX, Yates JR 3rd, Hopper AK, and Engelke DR.
PNAS 110: E3081-9

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2012

Impaired Generation of 12-Hydroxylated Bile Acids Links Hepatic Insulin Signaling with Dyslipidemia
Haeusler RA, Pratt-Hyatt M, Welch CL, Klaassen CD, and Accili D.
Cell Metabolism 15: 65-74

Regulation of hepatic LDL receptors by mTORC1 and PCSK9
Ai D, Chen C, Han S, Ganda A, Murphy AJ, Haeusler R, Thorp E, Accili D, Horton JD, and Tall AR.
Journal of Clinical Investigation 122: 1262-1270

 

2011

Dissociation of the Glucose and Lipid Regulatory Functions of FoxO1 by Targeted Knockin of Acetylation-Defective Alleles in Mice
Banks AS, Kim-Muller JY, Mastracci TL, Kofler NM, Qiang L, Haeusler RA, Jurczak MJ, Laznik D, Heinrich G, Samuel VT, Shulman GI, Papaioannou VE, and Accili D.
Cell Metabolism 14: 587-597

2010

FoxOs function synergistically to promote glucose production
Haeusler RA, Kaestner KH, and Accili D.
Journal of Biological Chemistry 285: 35245-35248

Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia
Haeusler RA, Han S, and Accili D.
Journal of Biological Chemistry 285: 26861-26868

Group photo


Group photo


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